岩倉 洋一郎 true D(6か月以上) DBA/1JJmsSlc D (more than 6 months) Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> D1;129S2-Il6<tm1Kopf> D1;129S2-Il6<tm1Kopf> Developed by Manfred Kopf, Max-Planck-Institut fur Immunbiologie in 1994. The mice were backcrossed to DBA/1 for at least 4 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo. RBRC05131 herpes simplex virus thymidine kinase promoter (HSV tk promoter), Neomycin resistance gene (E. coli), PolyA signal (SV40), mouse Il6 genomic DNA Yoichiro IWAKURA covid19_onset IL-6遺伝子欠損マウス。免疫能低下。加齢に従い軽度肥満。 D1-Il6 KO In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 368, 339-342 (1994).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Nature, 368, 339-342 (1994).<br>研究成果の公表にあたって謝辞の表明を必要とする。 1994年 Max-Planck-Institut fur Immunbiologie, Dr. Manfred Kopfらにより開発。 D3 ES細胞由来。東大医科研岩倉研でDBA/1に4世代戻し交配 (BRC寄託時)。 129S2/SvPas (D3) Immunology and Inflammation Research IL-6 knockout mice. Homozygous mutant mice show decreased immune competence. slight overweight with aging. 1994年 Max-Planck-Institut fur Immunbiologie, Dr. Manfred Kopfらにより開発。D3 ES細胞由来。東大医科研岩倉研でDBA/1に4世代戻し交配 (BRC寄託時)。129S2/SvPas (D3)